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Definition of the Ohio River from the Oxford Advanced Learner's Dictionary

 

the Ohio River

 
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a major river in the eastern central US. It begins at Pittsburgh, Pennsylvania, where the Allegheny River and Monongahela River come together, and flows 981 miles/1 578 kilometres past Cincinnati and into the Mississippi River at Cairo, Illinois. The Ohio was the main route to the West in the late 18th and early 19th centuries.