- 1very great; felt or experienced very strongly profound changes in the earth's climate My father's death had a profound effect on us all. The news came as a profound shock. The report has profound implications for schools. Her sense of disappointment was profound.
- 2showing great knowledge or understanding profound insights a profound book
- 3needing a lot of study or thought profound questions about life and death
- 4(medical) very serious; complete profound disability