- 1 large or important enough to have an effect or to be noticed a highly significant discovery The results of the experiment are not statistically significant. There are no significant differences between the two groups of students. Your work has shown a significant improvement. These views are held by a significant proportion of the population. It is significant that girls generally do better on examinations than boys. The drug has had no significant effect on stopping the spread of the disease. compare insignificant
- 2having a particular meaning It is significant that he changed his will only days before his death.
- 3[usually before noun] having a special or secret meaning that is not understood by everyone synonym meaningful a significant look/smile
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