the abbreviation for ‘compact disc read-only memory’ (a CD on which large amounts of information, sound and pictures can be stored, for use on a computer) The software package contains 5 CD-ROMs. The encyclopedia is available on CD-ROM. a CD-ROM drive (= in a computer) This dictionary is also available on CD-ROM. This is the CD-ROM edition of the encyclopedia. compare ROM Word Origin 1980s: acronym from compact disc read-only memory.