despondent (about something) (especially North American English) despondent (over something) sad, without much hope synonym dejected She was becoming increasingly despondent about the way things were going. There are times when it is hard not to feel despondent. See related entries: UnhappinessExtra examples He is increasingly despondent over losing his family. His work was rejected again and again, and he grew more and more despondent. Patients often feel despondent. She was feeling utterly despondent. It was a pretty despondent group that sat around the fire at the end of the day.