[intransitive] prickle (with something) (of skin, eyes, etc.) to sting or feel strange and unpleasant because you are frightened, angry, excited, etc. Her eyes prickled with tears. The thought made her prickle with excitement. The hairs on the back of my neck prickled when I heard the door open. (figurative) He prickled (= became angry) at the suggestion that it had been his fault.