despair noun definition in Unhappiness topic from the Oxford Advanced Learner's Dictionary

despair

 noun: Unhappiness topic
[uncountable] the feeling of having lost all hope She uttered a cry of despair. A deep sense of despair overwhelmed him. He gave up the struggle in despair. One harsh word would send her into the depths of despair. Eventually, driven to despair, he threw himself under a train.