the feeling of having lost all hope She uttered a cry of despair. A deep sense of despair overwhelmed him. He gave up the struggle in despair. One harsh word would send her into the depths of despair. Eventually, driven to despair, he threw himself under a train. see desperate
Idioms to make someone worried or unhappy, because they cannot help My handwriting was the despair of my teachers. See despair in the Oxford Advanced Learner's Dictionary